DNA Structure Discovered sixty Years Ago

One of the world's nearly of import scientific papers was published inwards the magazine Nature on Apr 25, 1953, lx years agone today.  The entire newspaper was only 1 page!  In the curt communication, James Watson together with Francis Crick non alone detailed the definitive construction of DNA (deoxyribonucleic acid)  but too proposed the unzipping machinery past times which the molecule could replicate itself.  They initially announced they had constitute "the cloak-and-dagger of life" at the Eagle Pub in Cambridge, England.    (See the deoxyribonucleic acid diagram from the actual newspaper to the right)

These 2 vivid men figured out the chemic construction of deoxyribonucleic acid without doing whatever experiments.  They started past times carefully digested together with and thus synthesizing the world's literature.  They attended conferences together with sought information anywhere they could notice it.  They were ridiculed for edifice stick models instead of conducting costly together with fourth dimension consuming lab investigations.  The solution to the beautiful double helix construction of deoxyribonucleic acid arose via the collaboration of biologist Watson together with physicist Crick.  Neither 1 of them had an elite agreement of chemistry.  They fifty-fifty challenged together with eventually proved incorrect the triple helix construction proposed past times famous pharmacist Linus Pauling.  

Sixty years later, their uncovering together with the subsequent interrogation on recombinant deoxyribonucleic acid together with genomic sequencing has transformed our lives.  Today, nosotros conduct maintain for granted our mightiness to "grow" human insulin inwards bioreactors together with target specific cancers amongst molecular designer drugs.  It is appropriate to intermission for only a 2d today together with give cheers the 2 dreamers who via their difficult move together with intuition discovered the construction of DNA.  Let's promise nosotros tin notice together with encourage many to a greater extent than dreamers similar Watson together with Crick.

AM

References:  Watson together with Crick,  Nature Apr 1953

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Platelet Rich Plasma Update, JBJS Webinar

Worldwide involvement inwards Platelet-Rich Plasma is increasing significantly.  471 novel publications get got appeared on PubMed most platelet-rich plasma inwards simply the final year, making it quite challenging to proceed upward amongst the published literature.  There has besides been a dramatic rising inwards Google "hits" for PRP to over 1.3 million.  (See the graphs below)   New information lately accepted for publication to the American Journal of Sports Medicine confirms the value of PRP inwards the handling of chronic lawn tennis elbow.  See American College of Surgeons Report on the paper.

Tonight the Journal of Bone in addition to Joint Surgery volition endure belongings a webinar on the topic.  Over K professionals get got already signed upward for the event.  This is totally unprecedented for a major, elite mag to sponsor a give-and-take on a unmarried specific biologic orthopedic topic.  Follow MD Mishra:  @ for existent fourth dimension updates most tonight's webinar.

Or, reckon joining the Biologic Orthopedic Society Group on LinkedIN to participate inwards a give-and-take most the webinar in addition to other biologic orthopedic topics.

AM

TotalTendon

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Platelet-rich Plasma Update from Toronto, ISAKOS 2013

The International Society of Arthroscopy, Knee Surgery in addition to Orthopaedic Sports Medicine (ISAKOS) is a gathering of several K professionals that is shortly taking house inward Toronto, Canada.  Today, a platelet-rich plasma (PRP), Instructional Course Lecture was offered to over 100 participants.  Lectures close how to purpose or non purpose PRP were given past times MD Rogerio Silva, MD Allan Mishra, MD Nicola Maffuli in addition to MD Steven Arnoczky.  At to the lowest degree 10 other PRP lectures were given at the conference including MD Mandeep Dhillion from Republic of Republic of India presenting his fantabulous report showing the value of PRP for articulatio genus osteoarthritis.  Basic scientific discipline papers past times MD Joon Lee et al from Korea besides showed a chondro-protective upshot of PRP subsequently astute ACL tears.  It is becoming increasingly hard to proceed upward alongside the dramatic rising inward PRP related presentations in addition to papers.  Overall, it is clear that in that place is increasing worldwide involvement inward this point-of-care, blood-derived bioactive treatment.  As the information matures nosotros volition amend sympathise how to purpose PRP to help aid for patients.  Presently, in that place is fantabulous marker 1 back upward for its purpose inward chronic lawn tennis elbow.

AM


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Platelet Rich Plasma Significantly Improves Outcomes for Tennis Elbow inward a 230 Patient Study

The American Journal of Sports Medicine (AJSM) has merely published the largest study evaluating platelet-rich plasma.  The 230 patient study was conducted over the course of education of to a greater extent than than 5 years together with represents the locomote of dozens of clinicians together with researchers.  Overall, it is clear from the information that the purpose of PRP to process chronic lawn tennis elbow results inward important reductions inward hurting together with elbow tenderness compared to an active command of needling of the elbow without PRP.  It is every bit good security together with toll effective compared to cortisone together with surgery.  This type of study is fourth dimension consuming together with expensive but volition assistance guide patient together with physicians decisions nearly how to best process chronic lawn tennis elbow.

Here is a lay press article on the article from Healio.

Read the total AJSM Abstract below.

AM
Total Tendon


Platelet-Rich Plasma Significantly Improves Clinical Outcomes inward Patients With Chronic Tennis Elbow
A Double-Blind, Prospective, Multicenter, Controlled Trial of 230 Patients

1. Allan K. Mishra, MD*,†, 
2. Nebojsa V. Skrepnik, MD, PhD‡,
3. Scott G. Edwards, MD§, 
4. Grant L. Jones, MD‖, 
5. Steven Sampson, DO¶,
6. Doug A. Vermillion, MD#, 
7. Matthew L. Ramsey, MD**, 
8. David C. Karli, MD, MBA†† and 
9. Arthur C. Rettig, MD‡‡

1. ^†Department of Orthopedic Surgery, Menlo Medical Clinic, Stanford University Medical Center, Menlo Park, California
2. ^‡Tucson Orthopaedic Institute, Tucson, Arizona
3. ^§Division of Hand together with Elbow Surgery, Georgetown University Hospital, Washington, District of Columbia
4. ^‖Department of Orthopaedic Surgery, The Ohio State University, Columbus, Ohio
5. ^¶The Orthohealing Center together with The Orthobiologic Institute, Los Angeles, California
6. ^#Orthopaedic Research Clinic, Anchorage, Alaska
7. ^**Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania
8. ^††The Steadman Clinic, Vail, Colorado
9. ^‡‡Methodist Sports Medicine, Indianapolis, Indiana
10. Investigation performed at Department of Orthopaedic Surgery, Menlo Medical Clinic, Stanford University Medical Center, Menlo Park, California

1. *Allan K. Mishra, MD, Department of Orthopedic Surgery, Menlo Medical Clinic, Stanford University Medical Center, 1300 Crane Street, Menlo Park, CA 94025 (e-mail: am@totaltendon.com).

Abstract

Background: Elbow tenderness together with hurting amongst resisted wrist extension are mutual manifestations of lateral epicondylar tendinopathy, every bit good known every bit lawn tennis elbow. Previous studies bring suggested platelet-rich plasma (PRP) to live a security together with effective therapy for lawn tennis elbow.

Purpose: To evaluate the clinical value of tendon needling amongst PRP inward patients amongst chronic lawn tennis elbow compared amongst an active command group.

Study Design: Randomized controlled trial; Level of evidence, 1.

Methods: A total of 230 patients amongst chronic lateral epicondylar tendinopathy were treated at 12 centers over 5 years. All patients had at to the lowest degree three months of symptoms together with had failed conventional therapy. There were no differences inward patients randomized to have PRP (n = 116) or active controls (n = 114). The PRP was prepared from venous whole blood at the quest of attention together with contained both concentrated platelets together with leukocytes. After receiving a local anesthetic, all patients had their extensor tendons needled amongst or without PRP. Patients together with investigators remained blinded to the handling grouping throughout the study.

Results: Patient outcomes were followed for upwards to 24 weeks. At 12 weeks (n = 192), the PRP-treated patients reported an improvement of 55.1% inward their hurting scores compared amongst 47.4% inward the active command grouping (P = .094). At 24 weeks (n = 119), the PRP-treated patients reported an improvement of 71.5% inward their hurting scores compared amongst 56.1% inward the command grouping (P = .027). The percent of patients reporting important elbow tenderness at 12 weeks was 37.4% inward the PRP grouping versus 48.4% inward the command grouping (P = .036). At 24 weeks, 29.1% of the PRP-treated patients reported important elbow tenderness versus 54.0% inward the command grouping (P < .001). Success rates for patients amongst 24 weeks of follow-up were 83.9% inward the PRP grouping compared amongst 68.3% inward the command grouping (P= .012). No important complications occurred inward either group.

Conclusion: Treatment of chronic lawn tennis elbow amongst leukocyte-enriched PRP is security together with results inward clinically meaningful improvements compared amongst an active command group.

The Biomet Biologics GPS device was used to produce the PRP for this study.

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Acupuncture amongst Gold for Knee Osteoarthritis

I convey treated thousands of patients alongside human knee arthritis together with never heard of gilt acupuncture equally an option.  In the most recent effect of the New England Journal of Medicine, a representative study discusses the topic.

Gold Acupuncture Knee X-ray

From the NEJM, 2013, See Link Below

Apparently, this shape of handling is mutual inward roughly Asian countries.  As you lot tin run into from the x-ray above, it looks similar a a bunch of pino needles or staples convey invaded the knee.  I create non know of whatsoever information supporting this type of approach only it does brand for a rattling interesting x-ray.

Here is a link to the New England Journal of Medicine Case Report:

http://www.nejm.org/doi/pdf/10.1056/NEJMicm1202540

Yoo together with Yoo NEJM 2013

Please postal service whatsoever comments or links to information nearly this theme below.

AM

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Losing Weight Helps Knee Arthritis Pain

Knee arthritis has no cure, simply 1 handling consistently decreases pain---Weight Loss.  It is non uncomplicated simply it is effective.

What stops patients amongst human knee arthritis from losing weight?
1.  No clear, uncomplicated programme that produces weight loss together with improves function.
2.  Lack of volition power
3.  No consistency

Here are a few uncomplicated tips:
1.  Eat 1 less seize amongst teeth of everything. (The one-less diet)
2.  Drink less soda together with alcohol
3.  Exercise

But you lot say, I can't do because my knees hurt.  I cannot count the publish of times I bring heard that one.  Instead of complaining.......
1.  Try stretching to start
2.  Try H2O aerobics
3.  Try an do wheel (30 minutes 3x/week)

Hamstring Stretch


Set a finish of losing three pounds to start.  You knees may experience similar you lot lost upward to xv pounds because of the articulation forces that hap peculiarly when you lot become upward together with downward stairs.

Always depository fiscal establishment lucifer amongst your ain MD prior to initiating whatsoever program.

Send me whatsoever tips on weight loss together with arthritis:  @bloodcure on twitter.

AM
TotalTendon


Published articles supporting weight loss for arthritis
http://www.ncbi.nlm.nih.gov/pubmed/23484617
http://www.ncbi.nlm.nih.gov/pubmed/22401872
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Best Initial Knee Stretch The Hammy (Knee OA, Part 3)

Your hamstring tendons start on your pelvis together with insert behind together with below your knee. In almost every person, these tendons tighten amongst time.  Stretching your hamstring tendons is i of the best exercises you lot tin flame create for your articulatio genus together with back.  One written report flora "individuals with together with without osteoarthritis of the knee are able to demonstrate immediate beneficial adaptations to a stretching intervention."
Reference

I recommend create a educate of iii hamstrings stretches, iii times PER DAY.  Stretching multiple times per 24-hour interval is meliorate than stretching entirely i time a 24-hour interval or non at all.  You may last surprised amongst your improved flexibility if you lot are consistent almost stretching.  See the video below for a uncomplicated stretch that tin flame done anywhere.  I telephone hollo upwardly it the "Hammy Stretch".



Start yesteryear placing your leg on a step, or depression table.  Keep your dorsum conduct together with your toes pointed toward the ceiling.  Then, only hinge frontwards at your waist.  You volition probable experience the stretch inward the dorsum of your thigh, articulatio genus together with calf.

Consistency is the fundamental to improvement.  Try this uncomplicated practise together with it volition assistance your overall articulatio genus wellness together with improve your mightiness to straightening your knee.  Hamstring stretching is similar sunscreen, it is best to start early on together with proceed to stretch throughout your life.

As always, banking concern gibe amongst your ain MD earlier initiatory of all whatever practise program.

Next time, nosotros discover the uncomplicated notwithstanding highly effective means to strengthen all of the musculus of your legs.

AM
TotalTendon
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Best Overall Exercise: PowerKnee Bike Program (Knee OA Part 4)

The PowerKnee Bike Program uses an upright practise wheel to piece of job out all of your leg muscles.  It is the best overall practise for human knee hurting in addition to arthritis because it tin sack produce in addition to then much for yous without pregnant touching on on the joint.   By only riding the practise wheel for thirty minutes three times per calendar week yous tin sack likewise amend your cardiovascular fitness in addition to burn downwards a bunch of calories.  See the video below for details.

Record the calories yous tin sack burn downwards inwards thirty minutes in addition to compare your results calendar week past times calendar week for a month.  If yous are consistent inwards applying the PowerKnee Bike Program yous convey an first-class adventure of decreasing your hurting in addition to improving your human knee function.

As always, depository fiscal establishment check amongst your Dr. earlier offset whatever practise program.

AM
TotalTendon

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Can Curry Cure Knee Arthritis?

It sounds similar a plot for a giddy Bollywood movie, but published information genuinely supports the persuasion that 1 of the fundamental components of curry pulverization tin plough over notice attention alleviate hurting for patients alongside human knee arthritis.

Curcumin, a brilliant yellowish spice constitute inward curry powder, late was constitute to accept the same efficacy equally ibuprofen (the active ingredient inward Motrin too Advil) for patients alongside human knee arthritis.  In a late published report of 367 human knee arthritis patients, researchers constitute 1500 mg of Curcuma domestica extract had the same effectiveness inward price of hurting reduction equally 1200 mg of ibuprofen at iv weeks (Kuptnirataikul et al). Importantly, the curcumin treated patients had less episodes of abdominal hurting or discomfort compared to the ibuprofen patients.  Importantly, around other published report of of the same dosage of curcumin (1500 mg) was constitute to accept meaning improvements inward price of hurting too physical business office when compared to placebo at half dozen weeks (Panahi et al).   Curcumin has been noted to block several substances involved inward the inflammatory pathway too too inhibits activation of costless radicals.  This could attention explicate why the spice industrial plant to trim back hurting inward arthritis patients.  

So adjacent fourth dimension your human knee starts to hurt, set downward the ibuprofen too hobble over to your favorite Indian or Thai eating theater for a tasty curry meal.  It may merely attention your knees experience better.

On a to a greater extent than serious note, the published information supports trying a curcumin supplement 1500 mg per twenty-four lx minutes menses divided inward 3 doses for 4-6 weeks for patients alongside human knee arthritis.  (See nautical chart below)

AM
TotalTendon

Pain Reduction inward Patients alongside Knee ArthritisKuptnirataikul et al

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Biologic Orthopedic Update from Las Vegas

The TOBI biologic orthopedic coming together this yesteryear weekend inward Las Vegas was only outstanding.  Dr. Steve Sampson set together an splendid collection of lectures in addition to thus followed yesteryear an impressive ultrasound anatomy session yesteryear medico Jay Smith from the Mayo Clinic.   Hands on injections in addition to os marrow aspiration inward a cadaver lab completed the stellar conference held at the Red Rock Resort.

Las Vegas Red Rock Area

Some highlights of the sessions.  We heard close the role of PRP inward soccer players from medico Imtiaz Ahmad from London, England, the role of PRP for osteoarthritis from medico Brian Cole from Chicago, the role of adipose-derived stalk cells for the handling of knee articulation osteoarthritis from medico Yun Choi from South Korea, minimally invasive techniques for articular cartilage harm from medico Neil Ghodadra from Los Angeles in addition to the Andrews Institute Experience using Biologics to Accelerate Healing from medico Adam Anz.   Lectures close hydrodissection using ultrasound (Dr. Lam, Hong Kong), the electrical flow landscape of disc regeneration challenges in addition to promises (Dr. Bae, Los Angeles) in addition to the value of mesenchymal stalk cells (Dr. Caplan, Cleveland) were too given.  That was exactly business office of twenty-four hours i of the conference.  Day 2 included several to a greater extent than interesting in addition to of import lectures.  I retrieve at that topographic point were over 300 attendees in addition to many to a greater extent than next the streaming video (including myself on twenty-four hours one).  In betwixt the lectures, discussions were carried out inward the hallways in addition to demo area.  Overall, it was a fantastic international event.

The champaign of biologic orthopedics is exploding.  Worldwide involvement inward minimally invasive techniques to process challenging musculoskeletal problems is ascent rapidly.  It volition nevertheless accept time, endeavour in addition to about luck to give away in addition to prepare clinically meaningful treatments.  The proficient word is, progress is definitely existence made toward these lofty goals.

AM
TotalTendon
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