Best Overall Exercise: PowerKnee Bike Program (Knee OA Part 4)

The PowerKnee Bike Program uses an upright practise wheel to piece of job out all of your leg muscles.  It is the best overall practise for human knee hurting in addition to arthritis because it tin sack produce in addition to then much for yous without pregnant touching on on the joint.   By only riding the practise wheel for thirty minutes three times per calendar week yous tin sack likewise amend your cardiovascular fitness in addition to burn downwards a bunch of calories.  See the video below for details.

Record the calories yous tin sack burn downwards inwards thirty minutes in addition to compare your results calendar week past times calendar week for a month.  If yous are consistent inwards applying the PowerKnee Bike Program yous convey an first-class adventure of decreasing your hurting in addition to improving your human knee function.

As always, depository fiscal establishment check amongst your Dr. earlier offset whatever practise program.

AM
TotalTendon

Sumber http://plateletrichplasma.blogspot.com

Can Stem Cells Cure Knee Arthritis?

Can Stem Cells Cure Knee Arthritis?

Unfortunately, the response to that query is non known today.  It is clear, however, that many new regenerative therapies are emerging to assist the tens of millions of patients worldwide that are suffering from knee articulation arthritis.

First, nosotros must explore what type of stalk cells could last helpful inwards the handling of arthritis.  Stem cells of diverse types tin last obtained from your blood (peripheral derived stalk cells), os marrow (mesenchymal stalk cells), fatty (adipose derived stalk cells), together with fifty-fifty from umbilical cord blood.  Studies today are exploring diverse ways to extract, purify together with concentrate many types of stalk cells.  The cells tin together with thus last injected equally a time out into your knee, used equally business office of surgical physical care for or fifty-fifty injected afterwards an operation.

Microfracture of Damaged Knee Cartilage

One recent written report (Vangsness et al 2014) showed how an injection of mesenchymal stalk cells could Pb to to a greater extent than meniscus tissue afterwards a knee articulation arthroscopy.  24% of the treated grouping were establish to cause got at to the lowest degree 15% increased meniscal volume.  This is a pocket-size sum inwards solely a a quarter of the patients but it does correspond a start.  Another written report published final twelvemonth (Saw et al 2013), injected peripheral derived stalk cells afterwards a microfracture physical care for together with noted improvement inwards the cartilage quality.  Other approaches (Pak et al 2014) purpose adipose derived stalk cells from liposuction inwards combination amongst platelet-rich plasma to care for meniscus tears.  Finally, a review (Anderson et al 2013) of potential stalk jail cellular telephone therapies for knee articulation cartilage outlines many potential together with emerging options.

Also, a multifariousness of procedures equally good purpose non-stem cells to care for arthritis of the knee.  One of the oldest is called autologous chondrocyte implantation.  This is where a biopsy of your ain cartilage is taken together with and thus grown inwards a lab.  The expanded cells together with and thus reimplanted into an arthritic lesion of the knee.  Another physical care for merely penetrates the os nether the defective cartilage.  This leads to leakage of to a greater extent than or less of the os marrow along amongst your ain the stalk cells inside the marrow into the defect.  This is called microfracture.  Yet to a greater extent than or less other physical care for uses juvenile cartilage that is minced together with and thus glued into a arthritic zone of the knee.

It is clear that at that topographic point are many competing approaches to the purpose of cells together with stalk cells to care for knee articulation arthritis.  None cause got "cured" the problem.   There is, however, an earnest worldwide enquiry essay that volition attain clinically meaningful options for clinicians together with patients.

Millions worldwide are waiting for that day.

AM
TotalTendon

References
Anderson et al 2013
Saw et al 2013
Vangsness et al 2014
Pak et al 2014

Sumber http://plateletrichplasma.blogspot.com

Fat Stem Cells attention Knee Arthritis

Knee Arthritis is a real hard job to solve.  Millions of patients endure daily from this progressive affliction state.  A diverseness of new biologic therapies are inwards development.

Stem cells tin come upward from a diverseness of sources including your ain fat.  These cells are known every bit adipose derived stalk cells.  A recent written report from Korea suggests at that topographic point is value using this type of prison theatre cellphone for human knee arthritis.  Researchers gave patients escalating dose of the cells together with flora the high dose resulted inwards improved hurting together with constituent scores.  They every bit good flora the cartilage defect defect size decreased field the book of cartilage inwards the human knee increased.

Fat Derived Stem Cells

This information is encouraging together with volition bespeak to hold upward repeated prior to wide clinical use.  (See abstract below)

For patients amongst this problem, the horizon is vivid amongst many potential options similar stalk cells from your ain fat.

AM
TotalTendon

Stem Cells. 2014 May;32(5):1254-66. doi: 10.1002/stem.1634.

Intra-articular injection of mesenchymal stem cells for the handling of osteoarthritis of the knee: a proof-of-concept clinical trial.

Jo CH1, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS.

Author information

Abstract

Mesenchymal stem cells (MSCs) are known to convey a potential for articular cartilage regeneration. However, virtually studies focused on focal cartilage defect through surgical implantation. For the handling of generalized cartilage loss inwards osteoarthritis, an alternative delivery strategy would hold upward to a greater extent than appropriate. The job of this written report was to assess the security together with efficacy of intra-articular injection of autologous adipose tissue derived MSCs (AD-MSCs) for knee osteoarthritis. We enrolled xviii patients amongst osteoarthritis of the knee and injected AD MSCs into the knee. The stage I written report consists of iii dose-escalation cohorts; the low-dose (1.0 × 10(7)cells), mid-dose (5.0 × 10(7)), together with high-dose (1.0 × 10(8)) grouping amongst iii patients each. The stage II included nine patients receiving the high-dose. The top dog outcomes were the security together with the Western Ontario together with McMaster Universities Osteoarthritis index (WOMAC) at vi months. Secondary outcomes included clinical, radiological, arthroscopic, together with histological evaluations. There was no treatment-related adverse event. The WOMAC marking improved at vi months afterward injection inwards the high-dose group. The size of cartilage defect decreased field the book of cartilage increased inwards the medial femoral together with tibial condyles of the high-dose group. Arthroscopy showed that the size of cartilage defect decreased inwards the medial femoral together with medial tibial condyles of the high-dose group. Histology demonstrated thick, hyaline-like cartilage regeneration. These results showed that intra-articular injection of 1.0 × 10(8) AD MSCs into the osteoarthritic knee improved constituent together with hurting of the knee joint without causing adverse events, together with reduced cartilage defects past times regeneration of hyaline-like articular cartilage.

Sumber http://plateletrichplasma.blogspot.com

Survivor Blood to live on used every mo an Ebola Treatment

The Ebola epidemic is spreading as well as at that topographic point is no cure.  Treatment options fifty-fifty inwards the USA are express because at that topographic point are no approved drugs as well as fifty-fifty the provide of experimental ones bring been exhausted.  (See Washington Post Article)

Is it possible that blood could cure Ebola?

That is precisely what the New York Times (read amount article here) is reporting equally a possible treatment.  The concept is truly pretty simple.  Patients who bring been infected amongst Ebola as well as hold upwards prepare antibodies to the virus.  These virus destroying proteins alive inwards the serum of the blood.  A transfusion of serum or maybe fifty-fifty whole blood may live the best selection equally a halt gap stair out to process the expanding lay out of patients amongst the disease.  The World Health Organization fifty-fifty has a specific guidance document on the topic.  (WHO convalescent blood for Ebola)

In this infinite over many years, I bring discussed how to role blood therapeutically for regenerative medicine.  Discussions most platelet-rich plasma, os marrow concentrates as well as stalk cells from peripheral blood bring focus primarily on orthopedic injuries as well as disorders.  Blood equally a handling for Ebola volition have to a greater extent than attending inwards this blog.  Anyone amongst blood expertise of whatever form should create whatever they tin to help.  Please ship service comments or ship me data most how blood is beingness used to process Ebola:   @bloodcure on Twitter.

The potential restorative powers of blood are considerable as well as if it is possible to halt the epidemic or at to the lowest degree deadening it downwardly yesteryear using the serum of survivors equally a treatment, nosotros should create everything nosotros tin create execute on that strategy inwards improver to pursuing containment, supportive care, as well as experimental drugs.

AM
TotalTendon


Sumber http://plateletrichplasma.blogspot.com

Will Kobe Bryant become to Nippon to Treat his Knee Arthritis?

Japan Accelerates Regenerative Medicine amongst Regulatory Reforms

Why the US Must Follow Their Lead

Sign the online petition supporting Regenerative Medicine

Kobe Bryant, an elite professional person athlete from the National Basketball Association’s Los Angeles Lakers, has gone to Federal Republic of Federal Republic of Germany multiple times to last treated amongst a part of his ain blood for his creaky, arthritic knees.  The argue why he went to Federal Republic of Federal Republic of Germany is simple.  He wanted to accept the best take away a opportunity to play at the highest flat inwards the NBA in addition to he had exhausted all his options inwards the United States.  He went in that location to last treated amongst a factor of his ain blood that targets the inflammation associated amongst knee articulation osteoarthritis.  The handling he received is non approved hither inwards the United States. 

Will he decease to Nihon adjacent fourth dimension to acquire the most advanced therapy?  That may occur because inwards Nov 2014 Japan enacted legislation creating a novel pathway that accelerates the blessing procedure for regenerative medicine products.  We hither inwards the US demand to figure out how to best accelerate our ain regenerative medicine efforts or proceed to spotter our elite athletes in addition to other patients attempt handling beyond our shores.  Let’s explore why Nihon acted boldly inwards favor of regenerative medicine. 

Influenza A virus subtype H5N1 Nobel Prize was awarded to Japanese researcher in addition to one-time orthopedic surgeon, Dr. Shinya Yamanaka inwards 2012 for his pioneering locomote on how to reprogram mature peel cells into pluripotent stalk cells.  His potentially life saving locomote in addition to the national pride associated amongst it helped Nihon acquire a worldwide leader inwards stalk prison theater cellular telephone research.  Importantly, Nihon has also prospectively pursued in addition to passed legislation that volition dramatically own regenerative medicine.  The province took a leap into a brilliant futurity final calendar week amongst the implementation of regulatory reforms directed at accelerating the evolution of cell-based treatments. 

The novel police line established a dissever pathway for regenerative medicine products apart from traditional drugs in addition to medical devices. The regulations also created a organization that fosters faster commercialization of novel biologic products in addition to tin atomic number 82 to fourth dimension express approvals for upward to 7 years.   Post marketplace information analysis volition proceed to confirm the security in addition to efficacy of the regenerative medicine products amongst the potential to revoke approvals. 

The activity past times the Japanese authorities creates the proper equilibrium betwixt the demand for accelerated approvals for prison theater cellular telephone based therapies that accept established efficacy piece ensuring production safety.  The typical stage one, stage 2 in addition to stage 3 trials for novel drugs are non a proper pathway for cell-based therapies that accept highly complex mechanisms of activity that may or may non last identified fifty-fifty amongst elite preclinical models.  Importantly, many cell-based products come upward straight from a patient’s ain torso in addition to hence accept a dramatically higher security profile. 

Americans are screaming for novel treatments for a diversity of hard problems such every bit arthritis, pump illness in addition to diabetes.  Regenerative medicine in addition to particularly cell-based treatments accept a take away a opportunity to assist process in addition to potentially cure these problems.  We demand to follow the Japanese atomic number 82 in addition to exercise like pathways inwards the United States.  Last twelvemonth during a see to Nihon in addition to its PMDA (the equivalent of the FDA), I was staggered past times how engaged they were nearly regenerative medicine in addition to receptive they were to agreement how to convey condom in addition to effective biologic products to their populace.

The US tin acquire a keen bargain from Japan’s enlightened approach to regenerative medicine.  Safety of class should last paramount.  The catch of a conditional, time-limited blessing amongst reimbursement strikes a perfect chord every bit nosotros attempt meliorate treatments for our patients at to a greater extent than affordable prices.  Competition volition arise to obtain approvals based on stage 2 trials that confirm security in addition to demonstrate a solid grade of efficacy.  Importantly, to a greater extent than contest volition atomic number 82 to meliorate options in addition to faster excogitation like to the reckoner manufacture over the final several decades. 

We demand to also emulate our Silicon Valley technology scientific discipline colleagues in addition to telephone telephone for a Medical Moore’s Law.  Identify a specific clinical problem, exercise a novel solution in addition to inside 5 years double the efficacy in addition to decrease the cost past times 50 percent.  Data analysis via powerful graphical algorithms should assistance amongst novel discoveries in addition to also assist amongst meliorate management of many diseases.  

We must attempt dramatically higher horizons instead of beingness satisfied amongst iterative improvements.  The Japanese authorities should last congratulated for passing regulatory reform in addition to implementing transformative solutions.  Sooner, non later, nosotros demand to uncovering ways to execute our ain regulatory reforms hither inwards the US to assist our patients in addition to to rest competitive on the footing stage inwards regenerative medicine.

Perhaps, in addition to so Kobe volition last treated inwards California instead of Federal Republic of Federal Republic of Germany or Japan.

Allan Mishra, MD

TotalTendon


Sign the online petition supporting Regenerative Medicine

Please ship service whatsoever comments or suggestions nearly how to safely accelerate regenerative medicine.

References

(http://www.nobelprize.org/nobel_prizes/medicine/laureates/2012/yamanaka-facts.html)

Accessed 11/30/14

http://www.pmda.go.jp/english/events/2014taiwan_sympo/14_Keynote1.pdf

Accessed 11/30/14

Sumber http://plateletrichplasma.blogspot.com

Microfracture Surgery Jadaveon Clowney

The Houston Texans' Jadeveon Clowney late underwent "microfracture" surgical physical care for on his ailing correct knee.  (See ESPN report)

The study suggests the talented Mr. Clowney volition hold upwards out for ix months or more.  Just what is microfracture surgical physical care for too why does it accept equally long to recovery equally it does for a infant to born?

Microfracture Surgery

Let's starting fourth dimension amongst the basics.  There are 2 types of cartilage inwards the knee.  The surface cartilage which covers the bone.  This is known equally articular cartilage too tin flame hold upwards idea of a type of cap or roofing of the terminate of the bone.  This cartilage is introduce inwards whatever joint.  In the knee, in that place is around other type of cartilage, the meniscus cartilage.  There are 2 menisci inwards the knee--medial (inside) too lateral (outside).  When the surface "articular" cartilage is damaged, the genu tin flame move quite painful peculiarly amongst loading too twisting.  Think rushing a passer for example.  Similar symptoms tin flame come about when the meniscus is torn.  It is ofttimes hard to distinguish betwixt the 2 inwards price of which i is the hurting generator.

Microfracture surgical physical care for is an endeavour to exercise a tire piece over a cartilage defect past times poking a hole inwards the terminate of the os too creating an access channel to the os marrow.  The os marrow too thence leaks out via the holes that are created too forms a clot which over fourth dimension tin flame help comprehend the defect.  It takes time, many months, for this surgical physical care for to move because the "patch" needs to mature.  This technique is useful for pocket-sized defects inwards the cartilage simply hasn't proven to hold upwards bully for larger defects.  We exercise non know the size of Mr. Clowney's genu cartilage injury.

Recent evidence suggests that the add-on of platelet-rich plasma tin flame lift microfracture surgical physical care for results.  This has been shown inwards basic science, preclinical too instantly clinical studies.

This type of surgical physical care for at such a immature historic current is clearly non a expert sign.  In the long run, he may require farther intervention.  Please read the postal service below for farther data close why nosotros demand to accelerate our regenerative medicine efforts.  Mr. Clowney is i of tens of millions of people worldwide amongst symptomatic cartilage damage.  We demand to maximize outcomes of today's surgical techniques too prepare novel procedures to help continue our athletes too patients inwards the game.

AM

TotalTendon



Sumber http://plateletrichplasma.blogspot.com

$87 Billion Dollars for Total Knee Replacements past times 2030?

We convey an epidemic of articulatio genus arthritis inwards the U.S. of A. amongst over 10 1000000 affected Americans (Ref).  Many treatments are prescribed amongst variable efficacy for this mutual problem.  When all else fails, articulatio genus replacement is frequently recommended.  This physical care for is overall highly successful but every bit good expensive.

In 2009, the CDC reported the estimated costs of articulatio genus replacement inwards the U.S. of A. to survive $28.5 billion dollars (Ref).  Published reports advise at that spot volition survive a take away for virtually 3.5 1000000 articulatio genus replacements inwards the U.S. of A. past times 2030 (See paper).  At a conservative full terms of $25,000 per surgery, that translates into $87 billion dollars. So, the projections advise the costs volition triple over the side past times side fifteen years.

That is $87 Billion Dollars precisely inwards the U.S. of A. to care for end-stage articulatio genus arthritis.  That is precisely the terms of articulatio genus replacements.  It does non include other surgical or non-operative costs.  It every bit good doesn't include handling of other potentially arthritic joints such every bit the hip or shoulder.

We tin sack as well as should at in i trial laid about an all-in ready on against arthritis.

Patients take away to deed on the root trace of treatment.  They tin sack assistance themselves amongst a programme of diet as well as exercise.  Simple exercises such every bit the QuadCrunch and Hamstring Stretching can survive quite helpful.  Riding a wheel is or then other means to exercise amongst arthritic knees.  Losing fifty-fifty a pocket-size total of weight tin sack resultant inwards less hurting as well as to a greater extent than function.

The practiced tidings is many novel treatments are inwards evolution to care for this hard problem.  The bad tidings is the assay is fractionated.  It is of import to annotation that articulatio genus arthritis is non precisely a illness of the cartilage.  There is dysfunction inwards muscle, tendon, ligament, cartilage as well as os when a patient has arthritis.  A improve agreement of the genetic as well as epigenetic causes of arthritis is every bit good needed.  We volition take away a systematic approach to treating all of the components of the illness inwards social club to survive successful.

On the horizon are a plethora of biologic treatments including platelet rich plasma, stalk cells as well as fifty-fifty cistron therapy.  We take away to covert these novel treatments produce the hard piece of employment that is needed to examine their security as well as value.

H5N1 coalition of patients, providers, payers, researchers as well as manufacture take away to come upwards together as well as execute on potential treatments as well as prevention strategies.  We cannot afford to locomote along amongst the condition quo as well as pass virtually $90 Billion Dollars on articulatio genus replacements inwards 2030.

Please postal service your comments or suggestions below.

AM
TotalTendon




Sumber http://plateletrichplasma.blogspot.com