Platelet Rich Plasma Significantly Improves Outcomes for Tennis Elbow inward a 230 Patient Study

The American Journal of Sports Medicine (AJSM) has merely published the largest study evaluating platelet-rich plasma.  The 230 patient study was conducted over the course of education of to a greater extent than than 5 years together with represents the locomote of dozens of clinicians together with researchers.  Overall, it is clear from the information that the purpose of PRP to process chronic lawn tennis elbow results inward important reductions inward hurting together with elbow tenderness compared to an active command of needling of the elbow without PRP.  It is every bit good security together with toll effective compared to cortisone together with surgery.  This type of study is fourth dimension consuming together with expensive but volition assistance guide patient together with physicians decisions nearly how to best process chronic lawn tennis elbow.

Here is a lay press article on the article from Healio.

Read the total AJSM Abstract below.

AM
Total Tendon


Platelet-Rich Plasma Significantly Improves Clinical Outcomes inward Patients With Chronic Tennis Elbow
A Double-Blind, Prospective, Multicenter, Controlled Trial of 230 Patients

1. Allan K. Mishra, MD*,†, 
2. Nebojsa V. Skrepnik, MD, PhD‡,
3. Scott G. Edwards, MD§, 
4. Grant L. Jones, MD‖, 
5. Steven Sampson, DO¶,
6. Doug A. Vermillion, MD#, 
7. Matthew L. Ramsey, MD**, 
8. David C. Karli, MD, MBA†† and 
9. Arthur C. Rettig, MD‡‡

1. ^†Department of Orthopedic Surgery, Menlo Medical Clinic, Stanford University Medical Center, Menlo Park, California
2. ^‡Tucson Orthopaedic Institute, Tucson, Arizona
3. ^§Division of Hand together with Elbow Surgery, Georgetown University Hospital, Washington, District of Columbia
4. ^‖Department of Orthopaedic Surgery, The Ohio State University, Columbus, Ohio
5. ^¶The Orthohealing Center together with The Orthobiologic Institute, Los Angeles, California
6. ^#Orthopaedic Research Clinic, Anchorage, Alaska
7. ^**Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania
8. ^††The Steadman Clinic, Vail, Colorado
9. ^‡‡Methodist Sports Medicine, Indianapolis, Indiana
10. Investigation performed at Department of Orthopaedic Surgery, Menlo Medical Clinic, Stanford University Medical Center, Menlo Park, California

1. *Allan K. Mishra, MD, Department of Orthopedic Surgery, Menlo Medical Clinic, Stanford University Medical Center, 1300 Crane Street, Menlo Park, CA 94025 (e-mail: am@totaltendon.com).

Abstract

Background: Elbow tenderness together with hurting amongst resisted wrist extension are mutual manifestations of lateral epicondylar tendinopathy, every bit good known every bit lawn tennis elbow. Previous studies bring suggested platelet-rich plasma (PRP) to live a security together with effective therapy for lawn tennis elbow.

Purpose: To evaluate the clinical value of tendon needling amongst PRP inward patients amongst chronic lawn tennis elbow compared amongst an active command group.

Study Design: Randomized controlled trial; Level of evidence, 1.

Methods: A total of 230 patients amongst chronic lateral epicondylar tendinopathy were treated at 12 centers over 5 years. All patients had at to the lowest degree three months of symptoms together with had failed conventional therapy. There were no differences inward patients randomized to have PRP (n = 116) or active controls (n = 114). The PRP was prepared from venous whole blood at the quest of attention together with contained both concentrated platelets together with leukocytes. After receiving a local anesthetic, all patients had their extensor tendons needled amongst or without PRP. Patients together with investigators remained blinded to the handling grouping throughout the study.

Results: Patient outcomes were followed for upwards to 24 weeks. At 12 weeks (n = 192), the PRP-treated patients reported an improvement of 55.1% inward their hurting scores compared amongst 47.4% inward the active command grouping (P = .094). At 24 weeks (n = 119), the PRP-treated patients reported an improvement of 71.5% inward their hurting scores compared amongst 56.1% inward the command grouping (P = .027). The percent of patients reporting important elbow tenderness at 12 weeks was 37.4% inward the PRP grouping versus 48.4% inward the command grouping (P = .036). At 24 weeks, 29.1% of the PRP-treated patients reported important elbow tenderness versus 54.0% inward the command grouping (P < .001). Success rates for patients amongst 24 weeks of follow-up were 83.9% inward the PRP grouping compared amongst 68.3% inward the command grouping (P= .012). No important complications occurred inward either group.

Conclusion: Treatment of chronic lawn tennis elbow amongst leukocyte-enriched PRP is security together with results inward clinically meaningful improvements compared amongst an active command group.

The Biomet Biologics GPS device was used to produce the PRP for this study.

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