AAOS Discussion well-nigh Platelet Rich Plasma

The American Academy of Orthopaedic Surgery late published a goodness panel give-and-take close platelet rich plasma (PRP).  Its destination was to attention clarify the many issues surrounding this novel therapy.  Dr. Allan Mishra, Dr. Freddie Fu, Dr. Steven Arnoczky as well as Dr. Jo Hannafin participated.  Below is an excerpt from the article:

Dr. Hannafin: I did a Google search as well as flora to a greater extent than than 400,000 citations for PRP treatment, including YouTube videos on how the physical care for is performed. Clearly, patients, physicians, as well as scientists are interested inward the role of PRP. What atmospheric condition is PRP existence used for?

Dr. Mishra: I role it almost solely inward treating tendinopathy, especially chronic tendinopathy that has failed to answer to other handling modalities. That would include atmospheric condition such equally chronic, recalcitrant lateral epicondylitis, patellar tendinopathy, as well as Achilles tendinopathy. I intend the data—and the run that I accept been doing for almost a decade now—provide the greatest back upwards for its role inward that area.

To read to a greater extent than of the article, click here.

AM

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Sports Illustrated Platelet Rich Plasma Article

Sports Illustrated late published an article most platelet rich plasma.

"While Galea's role of PRP on Tiger Woods and other athletes has stirred debate, the technique is non especially new. Allan Mishra, adjunct clinical assistant professor of orthopedic surgical procedure at the Stanford University Medical Center together with a pioneer of PRP therapy, has been using it for nearly a decade. In a breakthrough report concluding twelvemonth based on operate past times Mishra, PRP therapy performed significantly amend than cortisone -- together with amongst fewer side effects since it makes role of the patient's ain blood -- inwards the handling of chronic lateral elbow tendinosis, aka lawn tennis elbow. "I tin go nation pretty definitively that PRP is a reasonable choice for tendon [injuries]," Mishra says. "Now it needs to last studied inwards other applications."


The breakthrough report was truly performed past times doctor Taco Gosens from the Netherlands.  He together with his colleagues convey published the best clinical information to appointment on the role of platelet rich plasma for tendinopathy.  
To read to a greater extent than of the SI article, click here


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Embryonic Stem Cells used to Treat Spinal Cord Injury Patient

For the kickoff fourth dimension inwards history, embryonic stalk cells bring been used to process a patient amongst an shrewd spinal cord injury.  According to several reports the protocol calls for using the handling inside 2 weeks of the initial injury.  Geron, the fellowship sponsoring the lawsuit has spent years too tens of millions of dollars merely to instruct to this kickoff patient.  The hope is for this kickoff stage that security tin live on demonstrated.

We bring officially entered the era of biologic medicine.  For quite roughly fourth dimension at that spot has been promise, similar a shot at that spot is action.  It is difficult to compute the total of endeavor that has probable gone into getting to merely this point.  It is the researchers too peculiarly this kickoff brave but tragic patient that deserve the credit for this advancement.

In the future, the piece of job of either adult stalk cells or induced pluripotent stalk cells may expire a meliorate option.  For now, regardless of your opinion on the ethics of embryonic stalk cells this 24-hour interval must live on marked every bit a milestone.

AM
Total Tendon

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Platelet Rich Plasma 2011

2011 volition live on the twelvemonth nosotros attain down to figure out how to best operate platelet rich plasma.  For close a decade now, it has been employed equally a handling for a diversity of problems.  Last year, score 1 information was published showing how PRP is ameliorate than cortisone for lawn tennis elbow.  Other information revealed that achilles tendionpathy that is mild to moderate too that had NOT been treated did non become significantly ameliorate amongst PRP too practice compared to a saline injection too exercise.

This year, large specialty organizations accept dedicated fourth dimension to struggle the value of PRP.  Via this forums, nosotros volition larn from experts.  New formulations too indications volition emerge equally to a greater extent than or less volition fade.  These changes volition live on based on presentation too publication of elite data.

AM
Total Tendon
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Platelet Rich Plasma Tennis Elbow Study

Enrollment inwards the almost comprehensive platelet rich plasma written report to engagement was of late completed.  The written report is a double blind randomized lawsuit of 230 patients of PRP vs Saline for chronic lawn tennis elbow.  It followed the protocol outlined inwards the outset published written report on the topic. 
(American Journal of Sports Medicine--Mishra as well as Pavelko, 2006)

It volition conduct maintain 8-10 months to destination the follow upwards as well as analyze the information but it is a milestone to conduct maintain only completed enrollment inwards this of import investigation.  We tin all expect frontwards to the results.

AM
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RevaTen Platelet Rich Plasma Shows Promise every mo a Heart Attack Treatment

Researchers at the Stanford University School of Medicine, inward collaboration alongside BioParadox, Inc., own got published information supporting the utilization of RevaTen platelet-rich plasma equally a promising biologic handling for myocardial infarction (heart attack).


The findings were published online inward Cardiovascular Revascularization Medicine in addition to volition hold upwards presented at The Sixth International Conference on Cell Therapy for Cardiovascular Disease at Columbia University Medical Center, New York City, on Jan 20, 2011.

Platelet-rich plasma (PRP) has been identified equally a new biologic handling for injure healing in addition to sports-related injuries. Studies dot PRP stimulates jail mobile telephone repair via increase division liberate in addition to past times attracting reparative cells. Only recently, however, own got scientists begun to written report PRP's potential inward repairing damaged cardiovascular tissue.

Working alongside colleagues at Stanford University Medical Center, Pb writer Allan Mishra, MD, a leading PRP researcher, studied the effects of RevaTen PRP (a proprietary formulation of concentrated platelets in addition to white blood cells) on cardiac purpose afterwards inducing cardiac ischemia (damage to myocardial tissue caused past times blood restriction) inward mice. The query was conducted nether the direction of Robert Robbins, MD, chairman of the subdivision of cardiothoracic surgical operation at Stanford University.

In this written report of 28 mice, researchers induced ischemia past times either permanently occluding the left anterior descending artery (Group A) or temporarily ligating it for 45 minutes (Group B). The hearts were in addition to then injected alongside RevaTen PRP or saline control. In social club to assess cardiac purpose afterwards treatment, magnetic resonance images were taken at 7 days post-procedure (Group A) in addition to 21 days (Group B). Tissue from all hearts was collected for histopathologic evaluation.

In both groups, mice that received PRP afterwards ischemia had significantly improve cardiac purpose equally measured past times left ventricular ejection fraction on MRI than those that had been injected alongside saline only. In grouping A, the RevaTen-treated animals had 38% improve ejection fraction compared to saline controls. In grouping B, the RevaTen-treated animals had 28% improvement inward ejection fraction compared to controls. Additionally, less scar tissue was flora inward RevaTen-treated hearts than inward controls.

"Although this is an observational written report using an brute model, PRP mightiness someday hold upwards employed at the dot of attention to process patients who own got had a pump attack. This could save cardiac purpose in addition to boundary the progression to congestive pump failure," Dr. Mishra says. "Since myocardial infarction remains the leading campaign of decease inward industrial nations, RevaTen PRP may travel a powerful biologic tool inward fighting pump illness in addition to render toll savings." The authors caution that this is a preclinical written report in addition to that farther translational query is needed to empathise how RevaTen PRP mightiness function to repair and/or protect cardiovascular tissue.
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Platelet Rich Plasma Forum at AAOS

The American Academy of Orthopaedic Surgery as well as AAOS Now volition travel conducting a Platelet Rich Plasma Forum on Feb 14, 2011 only prior to the Annual Meeting inward San Diego.  Participating inward this coming together are an elite grouping of clinicians as well as researchers including but non express to doc James Andrews, doc Steven Arnoczky, doc Terry Canale, doc William Clancy, doc Freddie Fu, doc Taco Gosens, doc Elizaveta Kon, doc Nicola Maffulli, doc Robert Marx, doc Allan Mishra, doc Pietro Randelli, doc Scott Rodeo, as well as doc JR Woodall.

This grouping along alongside several others has been tasked alongside evaluating the Blue Planet of platelet rich plasma.  It volition travel the close comprehensive tidings of the topic alongside see to orthopedics as well as sports medicine.  The destination is to hopefully brand only about feel of how to best evaluate as well as potentially role PRP.

Stay tuned for details.

AM
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