RevaTen Platelet Rich Plasma Shows Promise every mo a Heart Attack Treatment

Researchers at the Stanford University School of Medicine, inward collaboration alongside BioParadox, Inc., own got published information supporting the utilization of RevaTen platelet-rich plasma equally a promising biologic handling for myocardial infarction (heart attack).


The findings were published online inward Cardiovascular Revascularization Medicine in addition to volition hold upwards presented at The Sixth International Conference on Cell Therapy for Cardiovascular Disease at Columbia University Medical Center, New York City, on Jan 20, 2011.

Platelet-rich plasma (PRP) has been identified equally a new biologic handling for injure healing in addition to sports-related injuries. Studies dot PRP stimulates jail mobile telephone repair via increase division liberate in addition to past times attracting reparative cells. Only recently, however, own got scientists begun to written report PRP's potential inward repairing damaged cardiovascular tissue.

Working alongside colleagues at Stanford University Medical Center, Pb writer Allan Mishra, MD, a leading PRP researcher, studied the effects of RevaTen PRP (a proprietary formulation of concentrated platelets in addition to white blood cells) on cardiac purpose afterwards inducing cardiac ischemia (damage to myocardial tissue caused past times blood restriction) inward mice. The query was conducted nether the direction of Robert Robbins, MD, chairman of the subdivision of cardiothoracic surgical operation at Stanford University.

In this written report of 28 mice, researchers induced ischemia past times either permanently occluding the left anterior descending artery (Group A) or temporarily ligating it for 45 minutes (Group B). The hearts were in addition to then injected alongside RevaTen PRP or saline control. In social club to assess cardiac purpose afterwards treatment, magnetic resonance images were taken at 7 days post-procedure (Group A) in addition to 21 days (Group B). Tissue from all hearts was collected for histopathologic evaluation.

In both groups, mice that received PRP afterwards ischemia had significantly improve cardiac purpose equally measured past times left ventricular ejection fraction on MRI than those that had been injected alongside saline only. In grouping A, the RevaTen-treated animals had 38% improve ejection fraction compared to saline controls. In grouping B, the RevaTen-treated animals had 28% improvement inward ejection fraction compared to controls. Additionally, less scar tissue was flora inward RevaTen-treated hearts than inward controls.

"Although this is an observational written report using an brute model, PRP mightiness someday hold upwards employed at the dot of attention to process patients who own got had a pump attack. This could save cardiac purpose in addition to boundary the progression to congestive pump failure," Dr. Mishra says. "Since myocardial infarction remains the leading campaign of decease inward industrial nations, RevaTen PRP may travel a powerful biologic tool inward fighting pump illness in addition to render toll savings." The authors caution that this is a preclinical written report in addition to that farther translational query is needed to empathise how RevaTen PRP mightiness function to repair and/or protect cardiovascular tissue.
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