Steroid Injections may Deplete Tendon Stem Cell Pools

Steroid injections are normally used for a number of musculoskeletal conditions.  There is increasing bear witness to advise this is non a expert consider particularly for tendon related problems such equally lawn tennis elbow or rotator cuff tendinopathy.  Clinical studies exclusively confirm brusque term hurting relief for cortisone injections.  Basic scientific discipline studies are straight off revealing that such injections may deplete tendon stems cells pools or increase the ask a opportunity of tendon rupture.  (See Abstract Below)

Platelet rich plasma has been shown to hold out superior to cortisone injection inwards a double blind randomized case at to the lowest degree for lawn tennis elbow.  When discussing the value of evolving biologic therapies it is crucial to compare them to normally used treatments.  In the illustration of cortisone for tendon related injuries as well as disorders at to the lowest degree for straight off PRP is the superior alternative based on basic scientific discipline as well as clinical publications for lawn tennis elbow.  (Gosens et al Study)

Allan Mishra, MD

@Bloodcure
TotalTendon

J Orthop Res. 2012 Aug 8. 

The effects of dexamethasone on human patellar tendon stalk cells: Implications for dexamethasone handling of tendon injury.

Zhang J, Keenan C, Wang JH.

Source

Abstract

Injection of Dexamethasone (Dex) is normally used inwards clinics to process tendon injury such as tendinopathy because of its anti-inflammatory capabilities. However, serious adverse effects accept been reported equally a final result of Dex treatment, such equally impaired tendon healing as well as tendon rupture...... Dex handling depletes the stalk jail cellular telephone puddle as well as leads to the formation of non-tendinous tissues (e.g., obese as well as cartilage-like tissues), which brand tendon susceptible to rupture. 

© 2012 Orthopaedic Research Society. Published past times Wiley Periodicals, Inc. 

Copyright © 2012 Orthopaedic Research Society.

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